After being framed for murder by the very vampires he's sworn to destory, Blade himself becomes the hunted. Captured by the vampire-corrupted police, he is soon released by a group of fellow vampire hunters known as the Nightstalkers.
Upon Blade’s release, Nightstalkers' Hannibal King and Abigail Whistler, the daughter of Blade’s former mentor, invite the Daywalker to take up arms alongside them against the vampire leader Danica Talos. Unbeknownst to them, Danica has a secret weapon of her own to take down the human race—the freshly resurrected Dracula.
Blade is back and this time the threat is worse than ever. He must team up with a group of vampire hunters known as the Nightstalkers to defeat the resurrected form of Dracula.