After a devastating attack that kills innocent bystanders and Lt. Colonel James Rhodes, Tony Stark escapes S.H.I.E.L.D. detainment and seeks vengeance on the mysterious attacker. Iron Man, with Black Widow and Hawkeye trailing behind, enlists the help of the Punisher to catch his foe. But Tony Stark and Frank Castle may have bit off more than they can chew when they find a deadly new bioweapon in the hands of Ezekial Stane, the person responsible for Rhodes's death.