Pico was given cybernetic enhancements by Donald Pierce, granting him superhuman strength and endurance.
Pico has telescoping legs cybernetic legs that extend more than two stories in height and hands that act as energy whips, which can spin rapidly to deflect small missiles. Pico is also a capable gymnast and speaks fluent Portuguese.
Pico carries twin high-caliber semiautomatic shotguns, he is an excellent shot.
The diminutive brothers Pico and Nyko Halfghanaghan where born in Sparta, Greece. Pico became involved with the time-traveling arms dealer Tolliver (Tyler Dayspring) and at some point he became Tolliver's right-hand man. Pico was responsible for guarding the mutant mercenary Domino (Neena Thurman), for more than a year, while the shape-shifter Copycat (Vanessa Carlyle]] impersonated Domino as a ploy to get close to her boss Cable (Nathan Summers) for Tolliver. Pico was eventually discovered by Cable and Copycat in a Sardinian Villa torturing Domino with an electric whip. When Pico confronted the interlopers Cable, unceremoniously shoot him in the head; Tolliver and Copycat's ex-boyfriend Deadpool (Wade Wilson), arrived moments later and in the ensuing conflict Pico was left for dead. Clinging hopelessly to his life, he was saved by Donald Pierce, who turned him into a cyborg.