Zodiac (Cartel) - a criminal cartel whose leaders wore Zodiac-themed costumes to emulate the abilities of their respective Zodiac signs

Zodiac (Darren Bentley) - former member of the Zodiac Cartel as Aquarius, gained ability to transform into personification of each of the Zodiac Cartel members

Zodiac (Mister Zodiac) - ancient Mesopotamian who could transform into any of the twelve Zodiac signs

Zodiac (LMDs) - group of androids created by Scorpio (Jacob Fury)

Zodiac (First Sign) - sought to remove astrological influence from mankind and take over the world

Zodiac (Ecliptic) - agents of Ecliptic, opposed by Alpha Flight, killed by Weapon X

Zodiac (World Trust) - helped Scorpio obtain the Zodiac Key

Zodiac (Young Avengers) - once held the United Nations hostage, opposed by Young Avengers