When Reed is accused of having purposefully exposed Susan, Johnny and Ben to the cosmic rays that transformed them into the Fantastic Four, the team is torn apart. But as Susan, Johnny and Ben individually wonder if Reed is capable of such a betrayal, they're attacked by the mastermind behind the plot against Reed – Doctor Doom! Now the team has to escape Doom's prisons in order to save Reed and prevent Doom from plunging the city into the Negative Zone.