Baron Mordo and Dormammu help Eddie Brock's cell-mate, Cletus Kasady, become the merciless villain known as Carnage. Dormammu uses Carnage to get himself into this world and the three set off to create chaos. Faced with more enemies than he can handle, Spider-Man turns to an old ally: Iron Man!

The Venom symbiote returns to Earth and reunites with Eddie Brock. He is ordered by Dormammu to steal a machine from Stark Enterprises capable of releasing Dormammu from his dimension. When Venom battles Spider-Man and War Machine, he is easily defeated. He soon gets help from Cletus Kasady, who has bonded with another symbiote to turn into...Carnage!

When Spider-Man discovers that his black costume is a living organism, he decides to use it to get back the Prometheum X. Meanwhile, Eddie Brock's lies eventually leads to his firing when Jameson realizes that he's been duped. Spider-Man eventually removes the symbiote after fighting the Shocker, only for it to find a new host, Eddie Brock.

Spider-Man comes across an alien symbiote that attaches itself to him and forms a new black costume. Meanwhile, Eddie Brock accuses Spider-Man of stealing a valuable rock which was really stolen by the Rhino. Now Spider-Man faces a $1,000,000 bounty for his capture.

With the super soldier serum in hand, Kingpin successfully tests it on Felicia Hardy, The Cat's daughter. Now the superpowered Black Cat, Felicia teams up with Spider-Man to rescue her father and stop Kingpin from using the serum for his own ends.

Still dealing with the loss of Mary Jane, Spider-Man's friend Robbie is framed of a crime. Spider-Man works with J. Jonah Jameson to clear his name.

After Dr. Crawford is mutated into a monster, Spider-Man and Black Cat team up with Kraven to help her. Meanwhile, Dr. Curt Conners races to find an antidote.

With the Time Dilation Accelerator, the Green Goblin trails Spider-Man and discovers his secret identity. Insane and equipped with the newly found information, The Green Goblin kidnaps Mary Jane Watson and takes her to the George Washington Bridge. Spider-Man races to save Mary Jane, but will it be too late?

Alistair Smythe, currently working as Silvermane's top scientist, kidnaps the Black Cat. He then bribes Spider-Man into capturing the Scorpion or the Vulture in exchange for her release, and plans to use their DNA to restore Silvermane's true physical appearance!

The Green Goblin and the Hobgoblin clash over Dr. Ohn's Time Dilation Accelerator. Meanwhile, Peter and Mary Jane are celebrating Felicia Hardy's engagement to Jason Macendale when it is revealed that Macendale is in fact the Hobgoblin!

Debra Whitman and Clay Marks locate Morbius and bring him to ESU to work on a cure. At the same time Herbert Landon and the Shocker are hired by the Kingpin to capture Morbius in an effort to unlock the secret to immortality. The Black Cat hears of the news and teams up with Spider-Man to stop the Kingpin and make sure Morbius doesn't lose control.

Ex-employee of Stark Industries, Dr. Jonathan Ohn, invents a portable interdimensional device that accidentally makes him a living embodiment of a portal. Calling himself the Spot, he tries to steal money to fund his research and his unstable invention creates a vortex that threaten to engulf New York.

While hunting a vampire in Eastern Europe, Blade discovers that Morbius is still alive. Meanwhile, Mirium, flies to New York to seek out the Neogenic Recombinator. Spider-Man, Black Cat, Morbius, Blade and others must try to stop Mirium before she turns everyone into vampires.

Harry Osborn begins to lose his mind and takes on the cowl of the Green Goblin. Meanwhile, Anna Watson suspects that Peter Parker is behind the disappearance of Mary Jane and asks the Punisher to locate her daughter. Spider-Man is faced with the task of stopping Harry without harming him while eluding the merciless Punisher!

Mary Jane finally gets her big break in recreating the movie role made famous by an actress, named Miranda Wilson. But when Mary Jane starts hearing her father's voice, she finds herself trapped in the catacombs below Wonder Studios in the clutches of a vengeful Miranda. To save Mary Jane, Spidey must team up with one of his greatest enemies...Mysterio.

"Down to Earth": Peter Parker is sent out by the Bugle to take photos of the giant meteor that recently crashed. He soon finds himself tied up as Green Men creep out of the South Pole caves to sacrifice the meteor to their Geyser God! Can Spider-Man make it through the cave creatures and man-sized Venus Fly-traps to prevent the Green Men from sacrificing the meteor and plunging Earth into Intergalactic Terror?

Peter proposes to Mary Jane and asks Doctor Connors to walk Mary Jane down the isle. But before they could celebrate, a group of Lizard-Men attack and bring them down into the sewers. Spider-Man finds himself in the battle of his life as he fights the Lizard-King and his horde of minions!

"Specialists and Slaves'": The Radiation Specialist is out of prison with a dastardly new plan to take over Manhattan! By luring Spider-Man out of the city with a runaway car, the Specialist uses Manhattan's only active Nuclear Reactor to take over the city, causing it to rise out of the Hudson River into the sky and turn New Yorkers into his Spider-Man hunting slaves!

Against his wishes, the Kingpin transforms Alistair Smythe into a half-cyborg, half-mutant creature to become the Ultimate Spider Slayer. Bitter about the betrayal, Smythe turns on his former boss and goes on a vendetta to destroy all the people responsible for his father's death.

Hobbie, a man with a troubled past, is released from prison with the help of Wilson Fisk and seeks to get revenge on his former boss, Iceberg. Fisk allows Hobbie to use a special suit to give him super-human powers as the Prowler, but with one caveat: that if he removes the suit, it will detonate!

''Revolt in the 5th Dimension'': Spider-Man comes up against The Infinita of Dimensia 5! As a key researcher for the Library of Garth crashes on Earth, it's up to Spider-Man to protect the entire library that's been saved on a tiny jewel! Will our Friendly Neighborhood Spider-Man be able to defeat the X-Ray Intelligence of the Infinata, or will he submit to their devious mind games?