When an old friend of Reed's shows up looking for help, the Fantastic Four are in for the fight of their lives! His name is Bruce Banner, and he has a terrible secret � he's the Incredible Hulk. And when Banner Hulks out and goes on a rampage through New York City, it's up to the FF to stop him. Can they protect New York from the Hulk? Can they protect the Hulk from the group that's hunting him? Most important of all, has Ben Grimm finally met his match?

Reed finally cures the Thing, but the cure also takes away all of his memories since the formation of the Fantastic Four. When the Mole Man attacks, She-Hulk must fill in for the Thing while the powerless Ben Grimm must find a way to save the day.

While Reed conducts an experiment designed to cure Ben Grimm, there's an energy disruption which causes the experiment to go haywire! Now the Fantastic Four's powers have switched, but they don't have time to get used to them before they have to save the city. Because the energy disruption that caused the accident was the work of Doctor Doom, and now the FF, new powers and all, have to stop Doom before he destroys the city with his scheme.

Reed summons one of his deep space probes back to the Baxter Building for repairs, only to find that someone has hitched a ride on it back to Earth: the Impossible Man! The small, impish alien seems harmless enough, but the Fantastic Four soon realize that this creature, who can turn into anything, has turned into a big problem for them! Now they have to figure out how to get the Impossible Man off the planet before he goes from 'annoying' to 'dangerous!'

When a cosmic-ray saturated piece of the Fantastic Four's space station falls to earth on the Jersey Shore, the clay of eccentric local sculptor Phillip Masters, becomes energized with the power to control the minds and actions of others. The sculptor becomes THE PUPPET MASTER and uses miniature clay versions of the Fantastic Four to control the real heroes. Puppet Master captures award-winning New York artists, including his own step-daughter, Alicia, in an attempt to take over his "rightful place" in the art world.

Susan and Johnny witness the arrival of Namor, the Sub-Mariner, who bans humankind from using the oceans of the world. Susan takes Johnny (who hates the water with a passion) under the sea, hoping to reason with Namor. Instead, the siblings become prisoners of Namor in the fabled city of Atlantis. Reed and Ben fight their way through a swath of undersea monsters to come to their rescue, but Namor proves to be a formidable foe. And even worse, impressed by Susan's eloquent pleas for peace, he decides to keep her in Atlantis as an ambassador.

When Johnny gives an unauthorized tour of Reed's lab to his friend Frankie, things go bad� real bad. Frankie is sucked into another dimension, and Johnny goes in after her to try and keep anyone from finding out! But what he didn't realize is that something came OUT of the dimensional portal as he went in: a harmless little bug. Now Johnny and Frankie are trapped and on the run while Reed, Ben and Susan are left to deal with that little bug. Which is growing. And multiplying. And eating its way through the Baxter Building.

One of Reed's experiments goes awry, causing the Fantastic Four to begin shrinking� and they're not stopping. Within hours, the FF will shrink out of existence unless Reed can reverse the effect. But at miniature size, even a trip to the lab becomes a challenge, even more so when HERBIE's security systems recognize the action figure sized FF as an infestation of rodents and begins to hunt them down! Even with a helping hand from the Astonishing Ant-Man, the FF are in for a giant-sized challenge.

The FF return home from an extra-dimensional adventure to find the Baxter Building and everyone in it just a little bit off. Their usually-angry neighbors are suddenly all too happy to chat. They come bearing strange gifts, and oddly enough, seem extremely interested in the FF's powers. Soon it becomes obvious that the Baxter Building has been invaded by shape-shifting aliens - THE SKRULLS! But as the FF discover, whenever you deal with Skrulls, there's always more going on than meets the eye!

The Fantastic Four are evicted from the Baxter Building! The sinister Puppet Master has managed to turn the entire city against the FF from inside his prison cell, and it's up to them to clear their good names. What's more, they must stop Puppet Master from completing his ultimate goal—to control the mind of every person on the planet!

Susan forces the rest of the team to take part in 'Fantastic Fifth for a Day,' an attempt to drum up a little good PR for the team. But the contest is interrupted by the return of the SKRULLS. The FF aren't exactly worried by the awkward shape shifting aliens� that is, until they reveal the SUPER SKRULL�a genetically altered warrior who possesses all of the Fantastic Four's powers! And the team realizes they're in real trouble when they learn the Super Skrull has teamed up with Ronan the Accuser! The team's only hope might lie in the hands of the 'Fantastic Fifth�' a nerdy teenager named Rupert.

The deviant monster GIGANTO bursts up from the underground, putting a quick stop to the Fantastic Four's day off. Now it's up to them to stop the monster from destroying the city, but the FF quickly realize that the giant monster has a specific target� the BAXTER BUILDING! The mystery of the monster's appearance will lead the FF deeper into Subterranea than they've ever gone, and right into a TRAP. The MOLE MAN sent Giganto to attack the FF, but has a grander scheme in the works. Because the only thing better than having Giganto destroy the FF is to control an ARMY of Gigantos.

The FANTASTIC FOUR fall into a trap and are taken to the NEGATIVE ZONE, where they're attacked by ANNIHILUS and his warriors. But all is not as it seems - something in the Zone is affecting the Four's powers. Things go from bad to worse when DOCTOR DOOM arrives, apparently in league with Annihilus! But Doom isn't one to share power, and he takes Annihilus' energy source back to Earth with him. But even if the Four can escape Annihilus, how can they defeat Doom, who now has the power to destroy the world?

When Reed is accused of having purposefully exposed Susan, Johnny and Ben to the cosmic rays that transformed them into the Fantastic Four, the team is torn apart. But as Susan, Johnny and Ben individually wonder if Reed is capable of such a betrayal, they're attacked by the mastermind behind the plot against Reed � Doctor Doom! Now the team has to escape Doom's prisons in order to save Reed and prevent Doom from plunging the city into the Negative Zone.

The Fantastic Four face the metallic menace of Doctor Doom!

Johnny finds himself facing down a hostile alien jury - and Ronan the Accuser.

"Return to Zenn-La": The Surfer finally finds Zenn-La, and is reunited with his beloved Shalla Bal. But things seem different, and the behavior of Shalla Bal gets increasingly strange and dangerous.

"The End of Eternity": Eternity and Infinity summon Silver Surfer to warn him that Thanos plans on changing the flow of time backwards and causing the end of the universe!

"The Forever War": The Silver Surfer asks the Kree for a meeting with the Supreme Intelligence in order to shed more light on his lost home planet. They agree, but only after he completes a task that sends him in the middle of an unending war between Adam Warlock and the Kree!

"Radical Justice": The Surfer is captured by Lord Glenn and the Wanderers and put on trial for the crimes of Galactus. His powers are taken away, turning him back to Norrin Radd. While held captive, two nearby stars explode and form a massive black hole. Now, Norrin Radd must regain his powers and save his captors!

"Second Foundation": Nova and the Silver Surfer's friendship starts to take a toll on Nova's responsibilities to Galactus. While searching for the Surfer's home planet, Zenn-La, they find themselves on an ancient Skrull planet, where they join a Skrull revolution!