In an alternate universe, Gwen Stacy is bitten by a radioactive spider and becomes a Super Heroine.
Ghost-Spider
Bitten by a genetically-altered spider, Earth-65's Gwen Stacy gains super-powers and becomes a vigilante after the death of her friend Peter Parker. Despite being hunted for his death, she proves herself to be a hero as Ghost-Spider.
On Earth-65, Gwen Stacy was bitten by a radioactive spider instead of Peter Parker. Taking the name Ghost-Spider (and affectionately called Spider-Gwen by her fans), she uses her great powers responsibly to protect New York and the Web of Life!