The Skin and Bones Club appeared to be a group of elite socialites who amused themselves by murdering other human beings. Whether the killings were sacrificial in nature or merely sport remains unrevealed, but it is clear that at least on one occasion, bets were placed for the last man to cut out an internal organ from their victim having to buy a round of drinks. The innocent's life was spared that day when The Undead G-Man and Knuckles O'Shaugnessy spoiled the Skin and Bones Club's plans.
It is yet unrevealed if the Skin and Bones Club is still active today.